PortaCellTec biosciences GmbH

PortaCellTec – the pathfinder for your drug

Drug transporter service

PortaCellTec (PCT) provides a broad spectrum of uptake and efflux transporter assays (e.g. OATs, OCTs, OATPs, MATEs, MDR1, BCRP, BSEP, MRPs) to investigate the inhibitory potential and substrate characteristics of your drug. As recommended by FDA and EMA, we perform in vitro transporter studies with validated drug transporters stably-transfected in HEK-293 cells.


New! Quantification of non-labeled substances by LC/MS




Efflux transporter service


Gene name Protein name Probe substrates Probe inhibitors Transporter assays
ABCB1 MDR1 rhodamine123 verapamil,
cyclosporineA,
LY335979
efflux transporter assay
ABCG2 BCRP estrone-3- sulfate Ko143, elacridar,
sulfosalazine
vesicle-based
transporter assay
ABCB11 BSEP taurocholate cyclosporineA,
glibenclamide,
rifampicin
vesicle-based
transporter assay
ABCC2 MRP2 CDCF MK-571
benzbromarone
efflux transporter assay



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PortaCellTec Biosciences GmbH

 

Weender Landstraße 94 -108
37075 Göttingen
Tel : +49 551 309 66440
E-mail: PortaCellTec



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PortaCellTec

News

New validated products:

  • MRP2
  • roct1

Events

2nd German Pharm-Tox Summit
Heidelberg, Germany
March 06-09, 2017

19th Barrier- and
Transporter-Meeting

Bad Herrenalb, Germany
May 15-17, 2017

14th European ISSX Meeting
Köln, Germany

June 26- 29, 2017

2nd Symposium on Transporters in Drug Discovery
London, UK
May 15-16, 2017



Münster Transporttage 2017
Münster, Germany
October 21 – 22, 2017

 


Guidance for Industry (FDA and EMA)

Publications

 

 

PortaCellTec